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H M Pinedo Selected Research

nolatrexed (AG337)

6/2003Thymidylate synthase inhibition triggers apoptosis via caspases-8 and -9 in both wild-type and mutant p53 colon cancer cell lines.
4/2000Downstream molecular determinants of response to 5-fluorouracil and antifolate thymidylate synthase inhibitors.
1/2000Differences in the induction of DNA damage, cell cycle arrest, and cell death by 5-fluorouracil and antifolates.

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H M Pinedo Research Topics

Disease

44Neoplasms (Cancer)
09/2008 - 01/2000
17Colonic Neoplasms (Colon Cancer)
07/2006 - 01/2000
15Colorectal Neoplasms (Colorectal Cancer)
03/2007 - 03/2000
13Neoplasm Metastasis (Metastasis)
07/2004 - 02/2000
11Ovarian Neoplasms (Ovarian Cancer)
06/2003 - 03/2000
6Breast Neoplasms (Breast Cancer)
09/2008 - 01/2000
6Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
10/2006 - 01/2000
6Melanoma (Melanoma, Malignant)
06/2006 - 08/2000
4Carcinoma (Carcinomatosis)
03/2005 - 05/2001
3Sarcoma (Soft Tissue Sarcoma)
01/2004 - 01/2000
3Renal Cell Carcinoma (Grawitz Tumor)
01/2003 - 09/2000
3Autoimmune Diseases (Autoimmune Disease)
08/2001 - 04/2000
3Lung Neoplasms (Lung Cancer)
03/2001 - 01/2000
2Hemorrhage
05/2004 - 06/2002
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
02/2004 - 06/2003
2Adenocarcinoma
02/2004 - 05/2001
2Dermatofibrosarcoma
10/2003 - 10/2003
2Small Cell Lung Carcinoma (Small Cell Lung Cancer)
06/2003 - 06/2001
2Infections
09/2002 - 06/2000
2Weight Loss (Weight Reduction)
05/2002 - 03/2000
2Hypoxia (Hypoxemia)
12/2001 - 02/2001
1Osteoporosis
06/2007
1Residual Neoplasm
07/2006
1Wounds and Injuries (Trauma)
06/2006
1Confusion (Bewilderment)
04/2004
1Stomach Neoplasms (Stomach Cancer)
03/2004

Drug/Important Bio-Agent (IBA)

17Fluorouracil (Carac)FDA LinkGeneric
01/2006 - 01/2000
13Proteins (Proteins, Gene)FDA Link
06/2006 - 01/2000
12GemcitabineFDA Link
10/2006 - 01/2000
10Cisplatin (Platino)FDA LinkGeneric
10/2006 - 01/2000
10Pharmaceutical PreparationsIBA
01/2004 - 01/2000
9Thymidylate SynthaseIBA
03/2007 - 03/2000
9Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
05/2004 - 01/2000
8Irinotecan (Camptosar)FDA LinkGeneric
01/2006 - 04/2000
7EnzymesIBA
06/2005 - 06/2000
6VaccinesIBA
07/2006 - 08/2000
6Doxorubicin (Adriamycin)FDA LinkGeneric
09/2002 - 01/2000
5Messenger RNA (mRNA)IBA
06/2006 - 10/2000
5ProdrugsIBA
06/2005 - 02/2001
5Biological ProductsIBA
03/2005 - 01/2000
4Paclitaxel (Taxol)FDA LinkGeneric
10/2006 - 01/2000
3AntigensIBA
07/2006 - 03/2001
3Leucovorin (Folinic Acid)FDA Link
01/2006 - 04/2002
3Epithelial Cell Adhesion MoleculeIBA
03/2005 - 02/2001
3Antineoplastic Agents (Antineoplastics)IBA
03/2005 - 03/2000
3Tyrosine Kinase InhibitorsIBA
10/2003 - 01/2003
3nolatrexed (AG337)IBA
06/2003 - 01/2000
3Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA
01/2003 - 09/2000
3Monoclonal AntibodiesIBA
02/2001 - 01/2000
3Cyclophosphamide (Cytoxan)FDA LinkGeneric
10/2000 - 01/2000
2Indicators and Reagents (Reagents)IBA
09/2008 - 12/2001
2EndostatinsIBA
10/2005 - 05/2004
2Carboxylesterase (Hydrolase S)IBA
06/2005 - 09/2002
2RNA (Ribonucleic Acid)IBA
07/2004 - 01/2000
2adenovirus receptorIBA
11/2003 - 05/2001
2Imatinib Mesylate (Gleevec)FDA Link
10/2003 - 10/2003
2Member 1 Subfamily B ATP Binding Cassette TransporterIBA
06/2003 - 06/2000
2exatecan (DX 8951f)IBA
06/2003 - 09/2002
2Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA
05/2003 - 01/2000
2Thymidine PhosphorylaseIBA
02/2003 - 03/2000
2Topotecan (Hycamtin)FDA LinkGeneric
09/2002 - 01/2000
2CamptothecinIBA
09/2002 - 10/2000
2Therapeutic UsesIBA
09/2002 - 03/2001
2ThrombinFDA Link
09/2002 - 02/2000
2ErbB Receptors (EGF Receptor)IBA
09/2002 - 06/2000
2Semaxinib (SU5416)IBA
09/2002 - 01/2000
2fas Receptor (CD95 Antigen)IBA
03/2002 - 02/2001
2Daunorubicin (Cerubidine)FDA LinkGeneric
06/2001 - 06/2000
2Cytarabine (Cytosar-U)FDA LinkGeneric
06/2001 - 06/2000
2Coxsackie and Adenovirus Receptor-Like Membrane ProteinIBA
05/2001 - 03/2001
2ParaffinIBA
02/2001 - 03/2000
2N- (4- doxorubicin- N- carbonyl(oxymethyl)phenyl)- O- glucuronyl carbamateIBA
02/2001 - 02/2001
2Folic Acid (Vitamin M)FDA LinkGeneric
09/2000 - 04/2000
2LigandsIBA
06/2000 - 04/2000
2raltitrexed (D 1694)IBA
05/2000 - 04/2000
2Pemetrexed (MTA)FDA Link
04/2000 - 01/2000
1Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
09/2008
1CD13 Antigens (Alanine Aminopeptidase)IBA
06/2006
1ubenimexIBA
06/2006
1Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA
06/2006
1Protein Isoforms (Isoforms)IBA
06/2006
1matrigelIBA
06/2006
1Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA
01/2006
1Oxaliplatin (Eloxatin)FDA LinkGeneric
01/2006
1Ganciclovir (Cytovene)FDA LinkGeneric
06/2005
1Thymidine KinaseIBA
06/2005
1BCG VaccineFDA Link
03/2005
1Surface Antigens (Surface Antigen)IBA
03/2005
1DNA (Deoxyribonucleic Acid)IBA
07/2004

Therapy/Procedure

20Therapeutics
09/2008 - 01/2000
16Drug Therapy (Chemotherapy)
09/2008 - 01/2000
6Immunotherapy
07/2006 - 01/2001
3Radiotherapy
12/2002 - 01/2000
2Intravenous Infusions
10/2005 - 06/2003
2Neoadjuvant Therapy
05/2003 - 01/2000
2Aftercare (After-Treatment)
06/2002 - 05/2000
2Metastasectomy
05/2002 - 08/2000
1TP protocol
10/2006
1Subcutaneous Injections
10/2005
1Combination Drug Therapy (Combination Chemotherapy)
02/2004